Clinical Study

Over Ten-Year Kidney Graft Survival Determinants

Table 2

Comparison of recipient, donor, and renal transplant characteristics between the two groups (graft function after 10 years versus graft loss within 10 years).

CharacteristicsG I (graft function after 10 years)G II (graft loss within 10 years)P value

Recipient
 Age (years), median [IQR]36.1 [28.1–47.1]35.8 [26.9–47.2]Ns
 Male gender, n (%)146 (57.5%)384 (60.2%)Ns
 Time on dialysis (years), median [IQR]2.7 [1.3–4.7]2.5 [1.4–5.6]Ns
 Body mass index (kg/m2), median [IQR]22.4 [20.3–24.2]22.2 [19.9–24.2]Ns
 Prior kidney transplant, n (%)56 (8.8%)17 (6.7%)Ns
 Positive CMV IgG, n (%)462 (73.9%)151 (62.1%)0.001
 Prior blood transfusion (≥3 units), n (%)235 (36.8%)115 (45.3%)0.023
Donor
 Age (years), median [IQR]24.0 [18.0–36.0]29.0 [20.0–46.0]<0.001
 Male gender, n (%)454 (77.2%)182 (74.6%)Ns
 Serum creatinine (mg/dL), median [IQR]1.0 [0.8–1.2]1.0 [0.8–1.2]Ns
Transplant
 0 mismatches HLA-B, n (%)139 (22.7%)42 (17.0%)0.002
 1 mismatches HLA-B, n (%)189 (30.9%)60 (24.3%)
 2 mismatches HLA-B, n (%)283 (46.3%)145 (58.7%)
 PRA ≥ 30%, n (%)18 (3.5%)16 (7.6%)0.031
 ATG induction protocol, n (%)313 (45.5%)98 (39.0%)0.005
 Delayed graft function, n (%)187 (29.3%)107 (42.1%)<0.001
 Acute rejection, n (%)163 (25.3%)120 (47.2%)<0.001
 Serum creatinine at 12 months (mg/dL), median [IQR]1.30 [1.10–1.60]1.60 [1.33–2.10]<0.001

IQR: interquartile range; IgG CMV: immunoglobulin cytomegalovirus; HLA: human leucocyte antigen; PRA: panel reactive antibody; ATG: antithymoglobulin.