Clinical Study

Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease

Table 1

Dialysis initiation criteria in Japan. According to the guidelines for introducing patients to dialysis issued by the Ministry of Health, Labour and Welfare of Japan, sum total of 60 or higher is indication for dialysis initiation.

ItemsScore

Fluid retention
Electrolyte abnormality
Gastrointestinal symptoms
Circulatory symptoms
Clinical symptomsNeurological symptoms
Hematological disorders
Vision disorders
High grade30
Intermediate grade20
Low grade10

serum creatinine (mg/d)
(creatinine clearance : CCr (mL/min))
Remnant Renal functionsCr 8 mg/mL or higher (CCr <10 mL/min)30
sCr 5~8 mg/mL (CCr 10~20 mL/min)20
sCr 3~5 mg/mL (CCr 20~30 mL/min)10

High grade: impossible to wake-up30
Impairment level of daily livingIntermediate grade: marked limitation of activity20
Low grade: slight limitation of activity10

Age10 years or less10
65 years or older10

Systemic vascular disorderExistence of systemic vascular disorder10