Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease

Table 5

Uni- and multivariate analyses of the delaying effect of AST-120 on dialysis initiation. Uni- and multivariate analyses showed anemic status, eGFR, and not receiving AST-120 medication as independent factors associated with a significant increase in risk of dialysis initiation.

Univariate analysis	𝑃 value	Hazard ratio	95% CI
Age, <66.2, versus ≥66.2	0.808	0.979	0.828–1.158
CVD, without versus with	0.883	1.013	0.828–1.158
DM, without versus with	0.918	1.009	0.854–1.191
Systolic BP, <140, versus ≥140	0.228	1.123	0.930–1.355
BMI, <22, versus ≥22	0.960	1.004	0.846–1.193
ACEls/ARBs, without versus with	0.778	1.026	0.859–1.225
Ca blocker, without versus with	0.414	0.902	0.705–1.155
Activated Vit-D, without versus with	0.725	0.968	0.809–1.159
Hb, <8.8, versus ≥8.8	0.064	0.853	0.721–1.010
Alb, <3.6 versus, ≥3.6	0.996	1.000	0.846–1.183
Corrected Ca, <8.4 versus ≥8.4	0.681	1.036	0.875–1.227
Urine protein (mg/dL)	0.087	1.000	1.000–1.001
Urine protein (g/day)	0.488	1.001	0.999–1.003
eGFR, <8.0, versus ≥8.0	0.007	0.784	0.657−0.937
AST-120, with versus without	0.000	1.812	1.530–2.145
Multivariate analysis
Hb, <8.8, versus ≥8.8	0.042	0.837	0.705–0.994
eGFR, <8.0, versus ≥8.0	0.005	0.773	0.645–0.925
AST-120, with versus without	0.000	1.881	1.586–2.231