Is There a Role for Mammalian Target of Rapamycin Inhibition in Renal Failure due to Mesangioproliferative Nephrotic Syndrome?

Figure 1

Hyperglycemia and PDGF stimulate mTOR, which in turn contribute to the nuclear translation of mRNAs necessary for cell growth and proliferation, clinically evident as hematuria, proteinuria, and glomerular filtration rate alterations.