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International Journal of Nephrology
Volume 2012, Article ID 608025, 5 pages
http://dx.doi.org/10.1155/2012/608025
Review Article

Influence of Birth Weight on the Renal Development and Kidney Diseases in Adulthood: Experimental and Clinical Evidence

1Division of Nephrology, School of Medicine, Federal University of São Paulo, 04023-062 São Paulo, SP, Brazil
2Department of Physiology, School of Medicine, Federal University of São Paulo, 04023-062 São Paulo, SP, Brazil
3Department of Molecular Cardiology, Cleveland Clinic, Cleveland, OH 44195, USA

Received 7 March 2012; Revised 18 April 2012; Accepted 2 May 2012

Academic Editor: Umberto Simeoni

Copyright © 2012 Maria C. P. Franco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Several clinical and experimental studies support the hypothesis that foetal programming is an important determinant of nephropathy, hypertension, coronary heart disease, and type 2 diabetes during adulthood. In this paper, the renal repercussions of foetal programming are emphasised, and the physiopathological mechanisms are discussed. The programming of renal diseases is detailed based on the findings of kidney development and functional parameters.