Renal Development and Blood Pressure in Offspring from Dams Submitted to High-Sodium Intake during Pregnancy and Lactation
Figure 1
Schematic representation of angiotensin II (AII)-induced extracellular signal-regulated protein kinase (ERK) activation. AII acts through the type 1 AII (AT1) and type 2 AII (AT2) membrane receptors initiating intracellular signaling, with MAPK phosphorylation and activation of transcription factors in the nucleus, resulting in mRNA production for mediators of cellular differentiation and proliferation. GTPase: guanosine triphosphatase; MAPKKK: MAPKK kinase; MAPKK: MAPK kinase; ERK: extracellular signal-regulated protein kinase.
