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International Journal of Nephrology
Volume 2013, Article ID 437857, 9 pages
Review Article

Bisphenol A in Chronic Kidney Disease

1Servicio de Nefrología, IIS-Fundación Jiménez Díaz and IRSIN, Madrid, Spain
2Unidad de Dialisis, Servicio de Nefrología, IIS-Fundación Jiménez Díaz, Avenida Reyes Católicos 2, 28040 Madrid, Spain
3Universidad Autónoma de Madrid, Spain
4Servicio de Nefrología, Hospital Clínico San Carlos, Profesor Martín Lagos s/n, 28040 Madrid, Spain
5Laboratorio de Fisiología Renal y Nefrología Experimental, Departamento de Fisiología, Universidad de Alcalá, Madrid, Spain
6Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain

Received 18 February 2013; Accepted 20 June 2013

Academic Editor: Vladimír Tesař

Copyright © 2013 Emilio González-Parra et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Phenols are uremic toxins of intestinal origin formed by bacteria during protein metabolism. Of these molecules, p-cresol is the most studied and has been associated with renal function impairment and vascular damage. Bisphenol A (BPA) is a molecule with structural similarity with phenols found in plastic food and beverage containers as well as in some dialyzers. BPA is considered an environmental toxicant based on animal and cell culture studies. Japanese authorities recently banned BPA use in baby bottles based on observational association studies in newborns. BPA is excreted in urine and uremic patients present higher serum levels, but there is insufficient evidence to set cut-off levels or to link BPA to any harmful effect in CKD. However, the renal elimination and potential exposure during dialysis warrant the monitoring of BPA exposure and the design of observational studies in which the potential health risks of BPA for end-stage renal disease patients are evaluated.