International Journal of Nephrology / 2013 / Article / Tab 1

Review Article

Periodontal Disease: A Covert Source of Inflammation in Chronic Kidney Disease Patients

Table 1

Interventional studies (impact of periodontal therapy on systemic inflammatory biomarkers).

StudyNo. of patientsType of studySerum inflammatory biomarkersResults

Ebersole et al., 1997 [52]34 pts/AP,
35 pts/ctrl
Prospective/2 yrs
interventional,
SRP at every 6 mos + Fb (5,15 or 50 mg/b.i.d.)
CRP, Hp CRP, Hp
at 2 yrs
D’Aiuto et al., 2004 [53]94 pts/SGPProspective/6 mos
interventional,
SPT (SRP)
CRP, IL-6 CRP, IL-6
at 6 mos
D’Aiuto et al., 2005 [54]65 pts/SGPProspective/2 mos
interventional,
IPT (SRP + Local Ab)
CRP, IL-6,
LDL chol
total chol
CRP, IL-6,
LDL chol
total chol
at 2 mos
D’Aiuto et al., 2006 [55]40 pts/SCGPProspective/6 mos
interventional
randomized
SPT/IPT
CRP, IL-6,
total chol
CRP, IL-6
total chol
at 2 and 6 mos in both groups but more important in the IPT group
Tonetti et al., 2007 [56]61 pts/SGP
RCT/Prospective/6 mos
interventional
IPT
CRP, IL-6
sE-selectin
transient, acute, short-term ↑ CRP, IL-6
CRP at 6 mos
sE-selectin
59 pts/ctrlSRP

AP: adult periodontitis; SGP: severe generalized periodontitis; SCGP: severe chronic generalized periodontitis; SRP: scaling and root planning; SPT: standard periodontal therapy; IPT: intensive periodontal therapy; Fb: flurbiprofen; Ab: antibiotic; CRP: C-reactive protein; IL-6: interleukin-6; LDL chol: LDL cholesterol; Hp: haptoglobin; sE-selectin: soluble E selectin; yrs: years; and mos: months.