Effect of the Direct Renin Inhibitor Aliskiren on Urinary Albumin Excretion in Spontaneous Type 2 Diabetic KK-𝐴^𝑦 Mouse

Figure 1

Expression of MMP-2, MMP-9, TIMP-1, TIMP-2, fibronectin, type IV collagen, MCP-1, and (P)RR in the kidneys of each mouse using real-time PCR (A: untreated KK mice at 8 weeks of age, B: untreated KK mice at 12 weeks of age, C: untreated KK-𝐴^𝑦 mice at 8 weeks of age, D: untreated KK-𝐴^𝑦 mice at 12 weeks of age, and E: treated KK-𝐴^𝑦 mice at 12 weeks of age). The ratio of MMP-2 (a), MMP-9 (b), TIMP-1 (c), TIMP-2 (d), fibronectin (e), type IV collagen (f), MCP-1 (g), and (P)RR (h) mRNAs to GAPDH mRNA is shown in the kidneys of mice from each group. These expressions were increased significantly in group 4 compared with groups 1, 2, and 3. This increase was attenuated in group 5 (*𝑃<0.001 versus untreated KK-𝐴^𝑦 mice at 12 weeks of age).

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)