Effect of the Direct Renin Inhibitor Aliskiren on Urinary Albumin Excretion in Spontaneous Type 2 Diabetic KK-𝐴^𝑦 Mouse

Figure 4

Mean protein levels of p-p38, p-ERK1/2, and p-SAPK/JNK in each mouse using Western blot analysis (A: untreated KK mice at 8 weeks of age, B: untreated KK mice at 12 weeks of age, C: untreated KK-𝐴^𝑦 mice at 8 weeks of age, D: untreated KK-𝐴^𝑦 mice at 12 weeks of age, and E: treated KK-𝐴^𝑦 mice at 12 weeks of age). The expression of p-p38 (a), p-ERK1/2 (b), and p-SAPK/JNK (c) proteins is shown in the kidneys of mice from each group. These expressions were increased significantly in group 4 compared with groups 1, 2, and 3. This increase was attenuated in group 5 (*𝑃<0.05 versus untreated KK-𝐴^𝑦 mice at 12 weeks of age).

(a)

(b)

(c)