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International Journal of Nephrology
Volume 2013 (2013), Article ID 650847, 7 pages
http://dx.doi.org/10.1155/2013/650847
Research Article

Haptoglobin Genotype and Risk Markers of Cardiovascular Disease in Patients with Chronic Kidney Disease

1Department of Nephrology, Aalborg Hospital, Aarhus University Hospital, Moelleparkvej 4, 9000 Aalborg, Denmark
2Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
3Department of Nephrology, Aarhus University Hospital, 8200 Aarhus N, Denmark
4Department of Clinical Biochemistry, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark

Received 3 December 2012; Revised 19 January 2013; Accepted 3 February 2013

Academic Editor: Alejandro Martín-Malo

Copyright © 2013 Charlotte Strandhave et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Sudden cardiac death and atherosclerosis have a major impact on cardiovascular mortality in chronic kidney disease (CKD). Inflammation with elevated high-sensitive C-reactive protein (hs-CRP) is involved in both sudden cardiac death and atherosclerosis, and decreased heart rate variability (HRV) is a predictor of both sudden cardiac death and atherosclerosis. Haptoglobin (Hp) is characterised by three genotypes (1-1, 2-1, and 2-2) with different antioxidant abilities. The aim was to examine whether HRV and hs-CRP were associated with Hp genotype in CKD patients. Fifty-six patients with CKD stage 2–5 were included. Hp genotype was determined by high-performance liquid chromatography. HRV was analysed from the 24 h Holter recordings. Hs-CRP was measured using an immunoturbidimetric assay. The results show that the HRV indices SDNN and SDANN were significantly lower in the Hp 2-2 patients ( and 0.04, resp.). In an adjusted linear regression model, Hp 2-2 was associated with both SDNN ( ) and SDANN ( ). Hs-CRP was higher in the Hp 2-2 patients ( ). In an adjusted linear regression model, the association between Hp 2-2 and hs-CRP remained significant ( ). In conclusion, a negative association was observed between Hp 2-2 and HRV, and Hp 2-2 was positively associated with hs-CRP in CKD patients.