Effect of AST-120 on Endothelial Dysfunction in Adenine-Induced Uremic Rats
Figure 4
Expression of adhesion molecules, growth factors, and endothelial dysfunction factor. Levels of ICAM-1, VCAM-1, TGF-β1, MCP-1, E-selection, PECAM-1, and ADMA mRNA in thoracic aorta were determined in the control and adenine rats at 7 weeks. (b) and (c): expressions of ICAM-1 and VCAM-1 mRNA in thoracic aorta. Quantitative RT-PCR of ICAM-1 and VCAM-1 using RNA extracted from the thoracic aorta in the control, control + AST-120, adenine, and adenine + AST-120 groups (). The relative mRNA level was calculated with the level of the control group set at 1. Data are expressed as mean ± SD of five rats in each group.
