Effect of AST-120 on Endothelial Dysfunction in Adenine-Induced Uremic Rats

Table 2

Comparison of characteristics and biochemical parameters.

Parameters	Control	Control + AST-120	Adenine	Adenine + AST-120
	(𝑛=6)	(𝑛=6)	(𝑛=6)	(𝑛=6)
BW (g)	458.5 ± 17.2	429.3 ± 20.5	309.5 ± 69.2^a,b	322.4 ± 51.3^a,b
SBP (mmHg)	131.00 ± 6.06	122.00 ± 5.57	136.6 ± 21.90^a	122.8 ± 9.27
S-UN (mg/dL)	25.00 ± 3.89	25.08 ± 7.65	113.52 ± 62.34^a,b	102.72 ± 34.41^a,b
S-Cr (mg/dL)	0.330 ± 0.026	0.284 ± 0.025	1.572 ± 0.561^a,b	1.334±0.452^a,b
Ca (mg/dL)	11.33 ± 0.98	11.48 ± 0.70	10.90 ± 1.35	11.40 ± 1.16
Pi (mg/dL)	11.33 ± 2.72	10.48 ± 0.88	13.04 ± 4.58	12.58 ± 1.33
Alb (g/dL)	4.38 ± 0.22	4.34 ± 0.15^c	4.12 ± 0.49	3.80 ± 0.28^c
iPTH (pg/mL)	<3	<3	<3	<3
CRP (mg/dL)	0.010 ± 0.00	0.010 ± 0.00	0.028 ± 0.040	0.012 ± 0.004
Indoxyl sulfate (𝜇g/mL)	1.61 ± 0.64	0.27 ± 0.19	40.82 ± 24.33^a,b	11.76 ± 11.14^d

All data are given as mean ± SD.
^a𝑃<0.01 versus control, ^b𝑃<0.01 versus control + AST-120, ^c𝑃<0.05 versus control, and ^d𝑃<0.01 versus adenine.
Abbreviations: SBP: systolic blood pressure; S-UN: serum urea nitrogen; S-Cr: serum creatinine; Ca: calcium; Pi: phosphorus; Alb: albumin; iPTH: intact parathyroid hormone; CRP: c-reactive protein.