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International Journal of Nephrology
Volume 2014, Article ID 284293, 5 pages
Research Article

Values of Alpha 1 Microglobulin Does Not Differ between Individuals with and without Family History of Balkan Endemic Nephropathy

Department of Nephrology, Clinic for Internal Diseases, Dialysis and Kidney Transplantation, University Clinical Centre Tuzla, Trnovac bb, 75000 Tuzla, Bosnia and Herzegovina

Received 22 August 2013; Accepted 4 November 2013; Published 19 January 2014

Academic Editor: Vladimír Tesař

Copyright © 2014 Mirna Aleckovic-Halilovic et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. The aim of this study was to compare urinary alpha 1 microglobulin (A1MG) in healthy individuals with and without family burden for Balkan endemic nephropathy (BEN) in an endemic village. Methods. Otherwise healthy inhabitants with microalbuminuria or proteinuria were divided into two groups: with ( ) and without ( ) family BEN burden and screened for urinary A1MG and A1MG/urine creatinine ratio. Results. Average value of urinary A1MG was  mg/L in group with and  mg/L in group without family history for BEN (NS, ). A1MG was higher than 10 mg/L in eight (33.33%) inhabitants with family history and in 12 (37.5%) without (NS, ). Average values of urinary A1MG/creatinine ratio were and in group with and group without family BEN history (NS, , resp.). Elevated values of this ratio were found in 13 (54.17%) inhabitants with and 14 (43.75%) without family history for BEN (NS, ). Conclusion. We did not find statistically significant difference in the examined markers between healthy individuals with and without family burden for BEN. We concluded that these markers are not predictive of risk for BEN.