Impaired Urine Dilution Capability in HIV Stable Patients

Table 4

Chaimowitz’ test specific results. Comparison between HIV groups and seronegative controls: median (range) values.

	HIV tenofovir group	HIV nontenofovir group	Seronegative controls	P value
Urine osmolarity (mOsm/L)	138.5 (38–594)	92 (37–323)	59 (31–62)	0.01
Free-water clearance (TALH function) (mL/min/1.73 m^2)	3.07 (−1.36–6.9)	5.5 (−0.42–8.6)	13.2 (10.1–18.2)	<0.001
Proximal sodium clearance (proximal tubular function) (mL/min/1.73 m^2)	1.15 (0.59–4.1)	1.4 (0.47–2.2)	13.3 (10.8–19.9)	0.0001
Distal sodium reabsorption (Henle) (%)	71 (18–93)	91 (61–98)	84 (81–90)	0.04
Osmolar clearance (mL/min/1.73 m^2)	2.17 (1.0–6.3)	2.6 (0.78–3.39)	2.4 (1.9–3.9)	0.005

TALH: thick ascending limb of the loop of Henle.