|
| Protein ID | Protein name | Biological process | Cellular compartment | Molecular function | Fold change (FSGS/normal) | Up/downregulation |
|
| CD59 | CD59 glycoprotein | Blood coagulation/cell surface receptor signaling pathway/negative regulation of apoptotic process | Anchored to external side of plasma membrane | Potent inhibitor of the complement membrane attack complex (MAC) action | 24.41 | |
|
| CD44 | CD44 antigen | Wound healing involved in inflammatory response/negative regulation of apoptotic process | External side of plasma membrane | Blood group antigen receptor | 22.95 | |
|
| IBP7 | Insulin-like growth factor-binding protein 7 | Negative regulation of cell proliferation/regulation of cell growth | Extracellular space | Insulin-like growth factor-binding | 13.06 | |
|
| UROM | Uromodulin | Negative regulation of cell proliferation/regulation of ion homeostasis | Apical plasma membrane/extracellular space | Calcium ion binding | 12.63 | |
|
| GRN | Granulin | Signal transduction/positive regulation of epithelial cell proliferation | Extracellular space | Growth factor activity | 11.08 | |
|
| SAP | Proactivator polypeptide | Regulation of lipid metabolic process/regulation of MAPK cascade | Extracellular space/lysosomal membrane | Enzyme activator activity/lipid binding | 9.73 | |
|
| TRFE | Serotransferrin | Transferrin transport/cellular iron ion homeostasis | Apical plasma membrane/basal plasma membrane/extracellular region | Ferric iron binding | 15.15 | |
|
| A1AT | Alpha-1-antitrypsin | Regulation of proteolysis/response to cytokine stimulus/blood coagulation | Extracellular space | Serine-type endopeptidase inhibitor activity | 11.52 | |
|
| ApoA-1 | Apolipoprotein A-I | Negative regulation of cytokine secretion involved in immune response/negative regulation of inflammatory response | Spherical high-density lipoprotein particle/secretory granule | High-density lipoprotein particle binding | 5.64 | |
|
| ANT3 | Antithrombin-III | Blood coagulation/negative regulation of inflammatory response/response to nutrient/regulation of proteolysis | Extracellular space/plasma membrane | Serine-type endopeptidase inhibitor activity | 5.18 | |
|
| A1AG1 | Alpha-1-acid glycoprotein 1 | Regulation of immune system process/acute-phase response | Extracellular space | Functioning as transport protein in the blood stream | 3.85 | |
|
| Robo4 | Roundabout homolog 4 | Cell differentiation/negative regulation of cell migration | External side of plasma membrane | Receptor activity | 3.09 | |
|
| DPEP1* | Dipeptidase 1 | Leukotriene metabolic process/negative regulation of apoptotic process | Extracellular space/anchored to membrane | Metallodipeptidase activity | — | — |
|
