Oral Postdialysis Cholecalciferol Supplementation in Patients on Maintenance Hemodialysis: A Dose-Response Approach
Table 2
Bimonthly development of the biological parameters, as well as the dose of the post-dialysis cholecalciferol supplements, and comparison with the results in patients not receiving vitamin D supplementation.
Month
Winter
Summer
Winter
ANOVA
Jan
March
May
July
Sept
Nov
Jan
n
26
26
26
26
24°
24
24
Mean 25(OH)D concentration (nmol/L)
Range of 25(OH)D concentrations (nmol/L)
5–57
34–140
65–170
89–199
80–174
59–157
53–138
Mean weekly dose of cholecalciferol (IU/week)
0
6000
Range of the weekly dose of cholecalciferol (IU)
0
all 6000
6000 or 12000
4000–12000
2000–12000
0–12000
0–12000
Distribution of the 25(OH)D concentrations
>150 nmol/L
0
0
30%
35%
8%
4%
0
75.1–150 nmol/L
0
69%
76%
65%
92%
92%
84%
50.1–75 nmol/L
4%
18%
4%
0
0
4%
16%
25.1–50 nmol/L
46%
13%
0
0
0
0
0
0–25 nmol/L
50%
0
0
0
0
0
0
Distribution of the weekly doses of the cholecalciferol supplement
8000–12000 (IU/week)
0
0
31%
27%
29%
29%
29%
6000 (IU/week)
0
100%
69%
42%
34%
29%
29%
0–4000 (IU/week)
0
0
0
31%
37%
42%
42%
Parameters of bone metabolism
Calcium (mmol/L)
NS
Phosphate (mmol/L)
NS
Alkaline phosphatase (U/L)
NS
iPTH (ng/L)
NS
Mean 1–25(OH)2D concentration (pmol/L)
NS
Unsupplemented patients ()
Mean 25(OH)D concentration (nmol/L)
Calcium (mmol/L)
NS
Phosphate (mmol/L)
NS
Alkaline phosphatase (U/L)
NS
iPTH (ng/L)
NS
Mean 1–25(OH)2D concentration (pmol/L)
NS
compared to baseline and to patients without vitamin D supplementation.
°Between months 6 and 8, one patient has undergone kidney transplantation and another died.
