Table 1: Baseline demographic, clinical, and laboratory values.

TotalScr−/CysC−Scr−/CysC+Scr+/CysC−Scr+/CysC+

Age in years, mean ± SD 56.3 ± 8.9 54.6 ± 9.8 57.1 ± 10.258.156.90.52
Male sex, (%) 70 (66)26 (68)17 (68)8 (53)19 (68)0.74
BMI, median (IQR)30.6 (25.7–36)32.2 (26.3–36.8)29.2 (25.5–32.6)33.2 (25.7–21.3)31.5 (25–36.5)0.41
Race (%)
 White76 (72)30 (79)17 (68)12 (80)17 (61)0.34
 Black 16 (15)4 (11)4 (16)2 (13)6 (21)0.67
 Hispanic12 (11)4 (11)3 (12)1 (7)4 (14)0.90
Diabetes (%)24 (23)12 (32)2 (8)3 (20)7 (25)0.16
Active cancer (%)13 (12)5 (13)2 (8)2 (13)4 (14)0.92
Baseline creatinine mg/dL, median (IQR)1.02 (0.8–1.3)1 (0.8–1.2)0.97 (0.8–1.2)1.1 (0.9–1.43)1.18 (0.8–1.56)0.12
CKDa34 (32)9 (24)8 (32)6 (40)11 (39)0.51
Cirrhosis etiology (%)
 Alcohol 32 (30)11 (29)12 (38)4 (27)5 (18)0.13
 Alcohol and HCV 27 (25)13 (34)3 (12)1 (7)10 (36)0.04
 HCV19 (18)6 (16)3 (12)2 (13)8 (29)0.45
 NASH 10 (9)2 (5)2 (8)3 (20)3 (11)0.40
 Cryptogenic 4 (4)1 (3)1 (4)2 (13)0 (0)0.16
 Autoimmune 7 (7)3 (8)2 (8)2 (13)0 (0)0.28
 Other8 (8)3 (8)2 (8)2 (13)1 (4)0.65
Previous complications of cirrhosis (%)
 Ascites81 (76)27 (71)21 (84)11 (73)22 (79)0.67
 Hepatic encephalopathy67 (63)22 (58)15 (60)11 (73)19 (68)0.68
 Variceal bleed24 (23)12 (32)5 (20)3 (20)4 (14)0.42
 SBP12 (12)3 (8)5 (20)2 (13)4 (14)0.55
Reason for admission (%)
 Hepatic encephalopathy26 (25)10 (26)4 (16)5 (33)7 (25)0.63
 Refractory ascites/edema16 (15)6 (16)4 (16)3 (20)3 (11)0.86
 AKI12 (11)3 (8)2 (8)2 (13)5 (18)0.60
 GI bleed8 (8)3 (8)1 (4)0 (0)4 (14)0.44
 Abdominal pain7 (7)4 (11)1 (4)1 (7)1 (4)0.78
 Jaundice5 (5)3 (8)1 (4)1 (7)0 (0)0.50
 Transplant work-up6 (6)1 (3)2 (8)1 (7)2 (7)0.70
 SBP4 (4)0 (0)2 (8)0 (0)2 (7)0.20
 Infection other than SBP4 (4)2 (5)1 (4)1 (7)0 (0)0.57
 Other20 (19)7 (18)7 (28)2 (13)4 (14)0.63
Child-Pugh Classb (%)0.17
 B37 (35)17 (45)6 (24)7 (47)7 (25)
 C69 (65)21 (55)19 (76)8 (53)21 (75)
Child-Pugh score, median (IQR)10 (9–12)10 (9–12)11 (10–12)10 (8–12)10 (10–12)0.39
MELD score, mean ± SD26.4 ± 9.525 ± 926.8 ± 9.823.8 ± 7.429.3 ± 10.50.20
Bilirubin, median (IQR)4 (1.8–9.1)3 (1.6–6.4)6.1 (2.6–9.6)3.8 (1.6–5.5)5.5 (2–16.7)0.31
INR, median (IQR)1.7 (1.3–2.3)1.5 (1.2–2.3)1.8 (1.4–2.3)1.6 (1.2–1.8)1.9 (1.4–2.7)0.08
Sodium, mean ± SD133 ± 6133 ± 6132 ± 7135 ± 7133 ± 70.74
Hyponatremia at enrollmentc (%)34 (32)12 (32)10 (40)5 (33)7 (25)0.71

aCKD defined as GFR < 60 mL/min calculated via CKD-EPI equation.
bChild-Pugh Class and MELD score at time of enrollment.
cSerum sodium <130 mEq/L.
SD: standard deviation; BMI: body mass index; IQR: interquartile range; CKD: chronic kidney disease; HCV: hepatitis C virus; NASH: nonalcoholic steatohepatitis; SBP: spontaneous bacterial peritonitis; MELD: model of end-stage liver disease; INR: international normalized ratio.