Comparison of CKD-EPI Cystatin C and Creatinine Glomerular Filtration Rate Estimation Equations in Asian Indians

Table 4

(a) Comparison of CKD stages by various equations versus the CKD-EPI creatinine 2009 equation. (b) Direction of eGFR changes by various equations compared to the CKD-EPI creatinine 2009 equation.

(a)

Equation	Estimated GFR categories by CKD-EPI creatinine 2009 equation (mL/min/1.73 m^2)
	>90		60–90		30–60		15–30		<15		Total
	Same; 𝑛 (%)	Different; 𝑛 (%)	Same; 𝑛 (%)	Different; 𝑛 (%)	Same; 𝑛 (%)	Different; 𝑛 (%)	Same; 𝑛 (%)	Different; 𝑛 (%)	Same; 𝑛 (%)	Different; 𝑛 (%)	Same; 𝑛 (%)
Cystatin C 2012 (age and sex)	895; (31.1)	600; (20.9)	706; (24.5)	471; (16.4)	141; (4.9)	50; (1.7)	8; (0.3)	3; (0.1)	3; (0.1)	0; (0.0)	1753; (60.9)
Creatinine-cystatin C 2012 (age, sex, and race)	1114; (38.7)	381; (13.2)	936; (32.5)	241; (8.4)	160; (5.6)	31; (1.1)	10; (0.3)	1; (0.03)	3; (0.1)	0; (0.0)	2223; (77.3)
Average of creatinine 2009 and cystatin C 2012	1110; (38.6)	385; (13.4)	960; (33.4)	217; (7.5)	163; (5.7)	28; (1.0)	10; (0.3)	1; (0.03)	3; (0.1)	0; (0.0)	2246; (78.1)
Spline Log cystatin C	1016; (35.3)	479; (16.6)	681; (23.7)	496; (17.2)	124; (4.3)	67; (2.3)	8; (0.3)	3; (0.1)	2; (0.1)	1; (0.03)	1831; (63.6)
Spline Log cystatin C—age, sex, and race	871; (30.3)	624; (21.7)	710; (24.7)	467; (16.2)	145; (5.0)	46; (1.6)	8; (0.3)	3; (0.1)	3; (0.1)	0; (0.0)	1737; (60.4)
Spline Log cystatin C—age, sex, and diabetes	936; (32.5)	559; (19.4)	702; (24.4)	475; (16.5)	134; (4.7)	57; (2.0)	6; (0.2)	5; (0.2)	2; (0.1)	1; (0.03)	1780; (61.9)
Spline Log cystatin C—age, sex, and weight	840; (29.2)	655; (22.8)	707; (24.6)	470; (16.3)	147; (5.1)	44; (1.5)	10; (0.3)	1; (0.03)	3; (0.1)	0; (0.0)	1707; (59.3)

(b)

Equation

Estimated GFR categories by CKD-EPI creatinine 2009 equation (mL/min/1.73 m^2)

>90

60–90

30–60

15–30

<15

Total

(𝑁 = number of patients classified differently from CKD-EPI creatinine 2009 equation)

Up; 𝑛 (%)

Down; 𝑛 (%)

Up; 𝑛 (%)

Down; 𝑛 (%)

Up; 𝑛 (%)

Down; 𝑛 (%)

Up; 𝑛 (%)

Down; 𝑛 (%)

Up; 𝑛 (%)

Down; 𝑛 (%)

Up; 𝑛 (%)

Down; 𝑛 (%)

Cystatin C 2012 (age and sex); (𝑁 = 1124, 39%)

0; (0.0)

600; (20.9)

264; (9.2)

207; (7.2)

39; (1.4)

11; (0.38)

3; (0.1)

0; (0.0)

0; (0.0)

0; (0.0)

306; (10.6)

818; (28.4)

Creatinine-cystatin C 2012 (age, sex, and race); (𝑁 = 654, 22.7%)

0; (0.0)

381; (13.2)

157; (5.5)

84; (2.9)

26; (0.9)

5; (0.17)

1; (0.03)

0; (0.0)

0; (0.0)

0; (0.0)

184; (6.4)

470; (16.3)

Average of creatinine 2009 and cystatin C 2012; (𝑁 = 631, 21.9%)

0; (0.0)

385; (13.4)

143; (5.0)

74; (2.6)

26; (0.9)

2; (0.07)

1; (0.03)

0; (0.0)

0; (0.0)

0; (0.0)

170; (5.9)

461; (16.0)

Spline Log cystatin C; (𝑁 = 1046, 36.4%)

0; (0.0)

479; (16.6)

361; (12.5)

135; (4.7)

60; (2.1)

7; (0.24)

3; (0.1)

0; (0.0)

1; (0.03)

0; (0.0)

425; (14.8)

621; (21.6)

Spline Log cystatin C—age, sex, and race; (𝑁 = 1140, 39.6%)

0; (0.0)

624; (21.7)

251; (8.7)

216; (7.5)

35; (1.2)

11; (0.38)

3; (0.1)

0; (0.0)

0; (0.0)

0; (0.0)

289; (10.0)

851; (29.6)

Spline Log cystatin C—age, sex, and diabetes; (𝑁 = 1097, 38.1%)

0; (0.0)

559; (19.4)

309; (10.7)

166; (5.8)

50; (1.7)

7; (0.24)

5; (0.17)

0; (0.0)

1; (0.03)

0; (0.0)

365; (12.7)

732; (25.4)

Spline Log cystatin C—age, sex, and weight; (𝑁 = 1170, 40.7%)

0; (0.0)

655; (22.8)

229; (8.0)

241; (8.4)

34; (1.2)

10; (0.3)

1; (0.03)

0; (0.0)

0; (0.0)

0; (0.0)

264; (9.2)

906; (31.5)