Estimation of Glomerular Filtration Rate Based on Serum Cystatin C versus Creatinine in a Uruguayan Population

Table 2

Differences between various estimates of GFR with eGFR derived from serum cystatin C as referent method.

Group		Difference in estimates of glomerular filtration rate (mL/min/1.73 m^2)
		eGFRmdrd	eGFRepi	eGFRmix
All participants	119	9.7	11.5	5.6
Women	68	11.3 (4.7–17.9)^‡	13.7	6.4
Men	51	7.5	8.7 (4.3–12.9)^‡	4.5
<60 years	57	3.2 (−4.1–10.4)	9.6 (3.9–15.3)^†	4.5 (2.1–6.8)^‡
≥60 years	62	15.6	13.3	6.6
Normotension	66	8.1 (0.9–15.3)*	10.4 (4.9–15.8)^‡	4.9
Hypertension	53	11.6	12.9	6.3
No diabetes	99	9.5 (4.7–14.4)^‡	11.9	5.7
Diabetes	20	10.3 (−0.7–21.3)	9.4 (0.7–18.1)*	4.9 (1.4–8.4)^†

eGFR_mdrd, eGFR_epi, and eGFR_mix indicate estimated glomerular filtration rate from serum creatinine according to the Modification of Diet in Renal Disease or the Chronic Kidney Disease Epidemiology Collaboration equations or from both serum cystatin C and creatinine. Differences were computed as eGFR_mdrd, eGFR_epi, or eGFR_mix minus GFR estimated from serum cystatin C (eGFR_cys). The values between brackets were the 95% confidence intervals (mean ± 1.96 standard errors). indicates the number of participants. Significance of the difference with eGFR_cys: *; ^†; ^‡; .