The Effects of Simvastatin on Proteinuria and Renal Function in Patients with Chronic Kidney Disease

Table 1

Patients’ characteristics.

	Simvastatin; ()	Nonsimvastatin; ()	value
Male (%)	17 (68%)	20 (76.9%)	0.556
Age (year)	62 ± 19.86	60.04 ± 21.31	0.735
Weight (kg)	67.80 ± 13.92	63.34 ± 13.80	0.256
Primary renal diseases, (%)			0.612
Glomerular diseases	11	9
CTIN	—	1
Unknown	14	16
Diabetes mellitus (%)	17 (68%)	8 (30.8%)	0.012
Hypertension (%)	21 (84%)	17 (65.4%)	0.199
Atherosclerosis (%)	6 (24.0%)	5 (19.2%)	0.743
Current antihypertensive agents (%)
ACEI/ARB	17 (68.0%)	18 (69.2%)	0.572
Diuretics	9 (36.0%)	5 (19.2%)	0.220
Alpha-blockers	9 (36.0%)	5 (19.2%)	0.220
Beta-blockers	5 (20.0%)	3 (11.5%)	0.171
CCB	7 (28.0%)	5 (19.2%)	0.258
SBP (mmHg)	139.08 ± 17.24	137.38 ± 17.88	0.732
DBP (mmHg)	79.44 ± 14.22	77.27 ± 13.26	0.575
UPCR (g/g creatinine)	0.96 (0.54, 2.9)	1.41 (0.66, 2.41)	0.445
GFR (mL/min/1.73 m^2)	41.12 ± 28.97	39.77 ± 23.55	0.856
BUN (mg/dL)	27.75 ± 12.68	30.60 ± 15.16	0.472
Serum creatinine (mg/dL)	1.97 ± 0.72	1.97 ± 0.73	0.995
Cholesterol (mg/dL)	211.72 ± 123.80	185.62 ± 57.15	0.335
Triglyceride (mg/dL)	158.48 ± 154.03	143.04 ± 112.93	0.684
HDL (mg/dL)	52.24 ± 15.05	57.19 ± 27.02	0.425
LDL (mg/dL)	134.04 ± 93.90	109.00 ± 42.80	0.232
Non-HDL (mg/dL)	157.56 ± 126.09	122.27 ± 55.55	0.199
AST (mg/dL)	24.80 ± 11.39	23.69 ± 10.88	0.724
ALT (mg/dL)	23.44 ± 19.07	21.04 ± 13.36	0.604

Values expressed as mean ± SD or median with interquartile ranges, ACEI: angiotensin converting enzyme inhibitor; ARB: angiotensin type 1 receptor blocker; ALT: alanine aminotransferase; AST: aspartate aminotransferase; BUN: blood urea nitrogen; CCB: calcium channel blockers; DBP: diastolic blood pressure; HDL: high density lipoprotein; LDL: low density lipoprotein; GFR: glomerular filtration rate; SBP: systolic blood pressure; UPCR: urine protein creatinine ratio.