The Effects of Simvastatin on Proteinuria and Renal Function in Patients with Chronic Kidney Disease
Table 3
Renal outcomes after 53 weeks of statin treatment.
Variables
Simvastatin
Nonsimvastatin
value between groups(&)
()
()
Baseline
At 53 weeks
Mean differences
value(#)
Baseline
At 53 weeks
Mean differences
value(#)
Mean UPCR (g/g creatinine)
2.26 ± 2.99
0.83 ± 0.95
−1.4 ± 2.8
0.019
1.79 ± 1.47
1.77 ± 2.68
−0.02 ± 2.4
0.969
0.049
Median UPCR (g/g creatinine)
0.96 (0.54, 2.9)
0.48 (0.18, 0.79)
<0.001
1.41 (0.66, 2.41)
1.21 (0.19, 1.56)
0.485
GFR (mL/min/1.73 m2)
41.12 ± 28.97
39.88 ± 29.74
−1.2 ± 7.2
0.396
39.77 ± 23.55
36.46 ± 18.82
−3.3 ± 11.9
0.168
0.458
Serum creatinine (mg/dL)
1.97 ± 0.73
2.06 ± 0.72
0.1 ± 0.62
0.315
1.97 ± 0.72
2.07 ± 0.67
0.1 ± 0.68
0.458
0.308
Values expressed as mean ± SD or median with interquartile ranges; GFR: glomerular filtration rate; UPCR: urine protein creatinine ratio; (#) comparisons within groups; (&) comparisons between groups.
