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International Journal of Nephrology
Volume 2015, Article ID 729609, 7 pages
Review Article

Arterial Stiffness and Renal Replacement Therapy: A Controversial Topic

1Favaloro University (AIDUF-CONICET), Solís 453, C1078AAI Buenos Aires, Argentina
2Technological National University, C1179AAQ Buenos Aires, Argentina
3Physiology Department, School of Medicine, CUiiDARTE, Republic University, 11800 Montevideo, Uruguay

Received 14 March 2015; Accepted 13 April 2015

Academic Editor: Francesca Mallamaci

Copyright © 2015 Edmundo Cabrera Fischer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The increase of arterial stiffness has been to have a significant impact on predicting mortality in end-stage renal disease patients. Pulse wave velocity (PWV) is a noninvasive, reliable parameter of regional arterial stiffness that integrates the vascular geometry and arterial wall intrinsic elasticity and is capable of predicting cardiovascular mortality in this patient population. Nevertheless, reports on PWV in dialyzed patients are contradictory and sometimes inconsistent: some reports claim the arterial wall stiffness increases (i.e., PWV increase), others claim that it is reduced, and some even state that it augments in the aorta while it simultaneously decreases in the brachial artery pathway. The purpose of this study was to analyze the literature in which longitudinal or transversal studies were performed in hemodialysis and/or peritoneal dialysis patients, in order to characterize arterial stiffness and the responsiveness to renal replacement therapy.