High (≥6.5) Spontaneous and Persistent Urinary pH Is Protective of Renal Function at Baseline and during Disease Course in Idiopathic Membranous Nephropathy

Table 1

Comparison of baseline and follow-up urinary pH and clinical, functional, and proteinuric parameters in 85 IMN patients with pH ≥ 6.5 (N 28) or pH < 6.5 (N 57).

Parameter	All patients	Pts. with pH ≥ 6.5	Pts. with pH < 6.5	value
	( = 85)	( = 28)	( = 57)
	Mean (±SD)	Mean (±SD)	Mean (±SD)
Baseline pH	5.96 ± 0.79	6.91 ± 0.36	5.50 ± 0.47	<0.0001
Follow-up pH	5.92 ± 0.58 (N 66)	6.44 ± 0.47 (N 23)	5.65 ± 0.47 (N 43)	<0.0001
Serum bicarbonate mEq/L	26.8 ± 3.4	27.7 ± 3.8	26.4 ± 3.6	0.13
Age (years)	52 ± 17	52 ± 21	52 ± 15	0.95
sCr (mg/dL)	1.20 ± 0.53	0.99 ± 0.34	1.31 ± 0.57	0.003
eGFR (mL/min/1.73 m^2)	73 ± 28	83 ± 28	68 ± 27	0.03
eGFR < 60 mL/min/1.73 m^2 (%)	32%	25%	35%	0.35
BP ≥140/90 mmHg (%)	53%	36%	61%	0.03
P/C ratio	3731 ± 2573	3649 ± 2288	3772 ± 2721	0.99
FE albumin	0.180 ± 0.170	0.160 ± 0.150	0.190 ± 0.180	0.50
FE IgG	0.05 ± 0.06	0.04 ± 0.06	0.05 ± 0.07	0.27
FE α1m-microglobulin	0.420 ± 0.410	0.290 ± 0.340	0.480 ± 0.440	0.02
NAG/C/eGFR	0.30 ± 0.30	0.21 ± 0.23	0.35 ± 0.32	0.04

Note: significant values are in bold.