Clinicopathological Correlation in Asian Patients with Biopsy-Proven Lupus Nephritis
Table 2
Renal findings at renal biopsy by LN class.
Total ()
Class II ()
Class III ()
Class IVG ()
Class IVS ()
Class V ()
Levels of clinical and laboratory findings
SBP (mmHg)
138.9 ± 22.7
118.4 ± 14.7
131.1 ± 17.9
144.2 ± 22.8*
139.3 ± 22.3*
134.6 ± 23.9
DBP (mmHg)
85.8 ± 14.4
76.1 ± 10.7
81 ± 12.1
89.5 ± 14.2†*
86.1 ± 14.8
81.1 ± 13.9
Hemoglobin (g/dL)
10.7 ± 2.2
12.5 ± 1.3
11.2 ± 2.2
10 ± 2.2†*
10.7 ± 1.5†
12 ± 1.9
BUN (mg/dL)
27.9 ± 21.4
14.7 ± 4.7
18.4 ± 12.3
33.5 ± 24.3†*
28.8 ± 17.4
22.2 ± 19.6
Serum creatinine (mg/dL)
1.3 ± 1
1.2 ± 0.8
0.9 ± 0.5
1.5 ± 1.1†
1.3 ± 1
1.1 ± 1.1
Estimated GFR (mL/min/1.73 m2)
80.2 ± 38.3
76 ± 32.4
98.2 ± 31.7
68.4 ± 37.2†
82 ± 36.9
95.3 ± 38.2
Serum cholesterol (mg/dL)
287.2 ± 107.6
225.7 ± 45.7
249.5 ± 74.5
296.2 ± 105.6
302 ± 138.3
297.3 ± 113.9
Serum albumin (g/dL)
2.9 ± 0.7
3.9 ± 0.5
3 ± 0.8*
2.8 ± 0.6*
2.9 ± 0.6*
2.9 ± 0.6*
UPCR (g/g creatinine)
4.4 ± 3.2
1.3 ± 0.5†
3.4 ± 2.4*
4.7 ± 3.3*
4.2 ± 2.4*
5.1 ± 3.8*
Percentages of clinical and laboratory findings
Hypertension (, %)
163 (66.8%)
3 (42.9%)
18 (47.4%)
92 (78.6%)†
26 (66.7%)
24 (55.8%)
Microscopic hematuria (, %)
157 (64.3%)
4 (57.1%)
24 (63.2%)†
86 (73.5%)†
29 (74.4%)†
14 (32.6%)
GFR < 50 mL/min/1.73 m2
68 (27.9%)
2 (28.6%)
5 (13.2%)
44 (37.6%)†
10 (25.6%)
7 (16.3%)
Nephrotic range proteinuria (, %)
125 (51.2%)
—
14 (36.8%)
67 (57.3%)*
19 (48.7%)*
25 (58.1%)*
Nephrotic syndrome (, %)
74 (30.3%)
—
7 (18.4%)
39 (33.3%)*
10 (25.6%)
18 (41.9%)*
Anti-dsDNA (, %)
190 (77.9%)
3 (42.9%)
33 (86.8%)*
92 (80.7%)*
32 (86.5%)*
30 (69.8%)
Data are mean ± SD, median with interquartile range and percentages; † < 0.05 versus class V and * < 0.05 versus class II. BUN: blood urea nitrogen, DBP: diastolic blood pressure, and GFR: glomerular filtration rate. UPCR: urine protein creatinine ratio and SBP: systolic blood pressure.
