Proteasome Activators, PA28α and PA28β, Govern Development of Microvascular Injury in Diabetic Nephropathy and Retinopathy
Light microscopic and TEM analysis of the glomeruli. (a) JMS-H&E and PAS staining of the nondiabetic and STZ-diabetic wild type and Pa28αβDKO glomeruli. Scale bars, 30 μm. (b) Ultrastructure of the glomeruli in wild type and Pa28αβDKO mice before and after STZ injection for indicated time points. Glomerular basement membrane (GBM), podocyte foot processes (PFP), endothelial cell fenestrae (ECF), and red blood cell (RBC) are shown. Scale bars, 1 μm. (c) Quantitation of the GBM thickness in TEM images of wild type and Pa28αβDKO glomeruli. (d) Quantitation of the average number of the EC fenestrae in TEM images of wild type and Pa28αβDKO glomeruli. N represents the number of animals in each experimental group. Results presented as mean ± SEM. , .
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