Proteasome Activators, PA28α and PA28β, Govern Development of Microvascular Injury in Diabetic Nephropathy and Retinopathy

Figure 6

The XAPC7 and HBX peptides inhibit the high glucose-induced OPN production in cultured mesangial cells. (a) Western blot analysis of the conditioned media of cultured wild type mesangial cells treated with XAPC7-TAT and scrambled XAPC7-TAT or (b) HBX-TAT and scrambled HBX-TAT peptides under high glucose (HG, 25 mM) conditions. (c) Western blot analysis of the conditioned media of cultured wild type mesangial cells treated with TAT peptide under high glucose (25 mM) conditions. (d) Western blot analysis of the conditioned media of cultured wild type mesangial cells treated with Chariot/XAPC7, Chariot/HBX, and Chariot/scramble peptides under high glucose conditions (25 mM).

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