Review Article

Acute Kidney Injury in Hematopoietic Stem Cell Transplantation: A Review

Table 1

Definitions and classification systems used for acute kidney injury.

Study/criteriaClassificationDefinition

Hingorani et al. (2015)AKIRise in Sr Cr of 0.3 mg/dL in <48 hrs and/or 1.5 times the previous level in <7 days

Kang et al. (2012)AKIRise in Sr Cr to twice its initial value
Severe AKIRise in Sr Cr to the level that requires dialysis

Yu et al. (2010)
Caliskan et al. (2006)
Grade 0Fall in GFR < 25% of the baseline value
Grade 1Fall in baseline GFR 25% or more and rise in Sr Cr < 2-fold
Grade 2More than or equal to 2-fold increase in Sr Cr without requiring dialysis
Grade 3More than or equal to 2-fold increase in Sr Cr requiring dialysis

Zhou et al. (2009)
Lopes et al. (2006)
AKIDoubling of Sr Cr in the first 100 days after transplantation

AKI network criteria (2007) Stage 1Rise in Sr Cr to >0.3 mg/dL or 1.5–2 times baseline value or fall in urine output to <0.5 mL/kg/h for >6 hrs
Stage 2Rise in Sr Cr 2-3 times baseline value or fall in urine output to <0.5 mL/kg/h for >12 hrs
Stage 3Rise in Sr Cr > 3 times baseline value or fall in urine output to <0.3 mL/kg/h for 24 hrs or anuria for 12 hrs

RIFLE criteria (2004) by ADQI groupAKI-R (risk)Rise in Sr Cr 1.5 times baseline value or fall in GFR > 25% or fall in urine output to <0.5 mL/kg/h for 6 hrs
AKI-I (injury)Rise in Sr Cr 2 times the baseline value or fall in GFR > 50% or fall in urine output to <0.5 mL/kg/h for 12 hrs
AKI-F (failure)Rise in Sr Cr 3 times the baseline value or fall in GFR by 75% or Sr Cr > 4 mg/dL or fall in urine output to less than 0.3 mL/kg/h for 24 hrs or anuria for 12 hrs
Persistent ARFTotal loss of kidney functions requiring dialysis > 4 weeks
End stage renal diseaseRequirement of dialysis for >3 months

AKI: acute kidney injury, Sr: serum, Cr: creatinine, GFR: glomerular filtration rate, ARF: acute renal failure, and ADQI: acute dialysis quality initiative.