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International Journal of Nephrology
Volume 2017, Article ID 2739539, 9 pages
https://doi.org/10.1155/2017/2739539
Research Article

Febuxostat Attenuates Renal Damage besides Exerting Hypouricemic Effect in Streptozotocin-Induced Diabetic Rats

1Department of Endocrinology, Guangzhou Red Cross Hospital, Medical School of Jinan University, No. 396 Tong Fu Zhong Road, Guangzhou, China
2Guangzhou Institute of Disease-Oriented Nutritional Research, Guangzhou Red Cross Hospital, Medical School of Jinan University, No. 396 Tong Fu Zhong Road, Guangzhou, China
3Department of Nephrology, Guangzhou Red Cross Hospital, Medical School of Jinan University, No. 396 Tong Fu Zhong Road, Guangzhou, China
4Southern Medical University, No. 1023-1063 Southern Sha Tai Road, Guangzhou, China

Correspondence should be addressed to Jianmin Ran; moc.nsm@mjnar

Received 3 March 2017; Revised 20 March 2017; Accepted 27 March 2017; Published 19 April 2017

Academic Editor: Franca Anglani

Copyright © 2017 Jianmin Ran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. In this study, we aimed to investigate the effects of febuxostat, a novel inhibitor of xanthine oxidase (XO), on renal damage in streptozotocin- (STZ-) induced diabetic rats. Methods. Diabetes was induced by the intraperitoneal injection of STZ in male Sprague-Dawley rats. Sham-injected rats served as controls. The control and diabetic rats were treated with and without febuxostat for 8 weeks, respectively. Fasting blood and 24-h urine samples were collected every 4 weeks. Rat livers were extracted for detecting gene expression, content, and bioactivity of XO. Results. Diabetic rats showed significantly increased serum uric acid (SUA), serum creatinine (SCr), and urea nitrogen (BUN) levels. Daily urinary albumin (UAE), uric acid (UUA), and creatinine (UCr) excretion were also significantly increased in these rats. In diabetic rats, at week 8, febuxostat decreased SUA by 18.9%, while UAA was increased by 52.0%. However, UCr and urinary urea nitrogen (UUN) levels remained unchanged, while SCr and BUN levels decreased by >30% in these rats. Although hepatic gene expression, content, and activity of XO increased significantly in diabetic rats, febuxostat only slightly decreased its content. Conclusions. Febuxostat significantly attenuated renal damage in STZ-induced diabetic rats in addition to exerting hypouricemic effect.