Time course of food intake, water intake, body weight, and main vital signs during the experiment after induction of diabetes. Heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were recorded by an indirect tail-cuff method. The circle with solid and dashed lines represents NC and NC + Fx groups, respectively, while the block symbol with solid and dashed lines shows data of DM and DM + Fx groups, respectively. Data are expressed as mean ± SD. Statistical significance () was labeled as , #, and correspondingly, when the DM + Fx group was compared with NC, NC + Fx, and DM groups.