High Serum Alkaline Phosphatase, Hypercalcaemia, Race, and Mortality in South African Maintenance Haemodialysis Patients
Table 4
Crude and adjusted hazard ratio (95% CI) of primary outcome by baseline characteristics.
Parameter
Crude HR
95% CI
Adjusted HR
95% CI
TAP > 112 U/L
2.20
1.12–4.32
0.02
2.50
1.24–5.01
0.01
Calcium (mmol/L)
<2.10
0.66
0.32–1.35
0.26
0.97
0.22–4.26
0.97
≥2.10–≤2.37
1.00
Reference
>2.37–≤2.75
2.31
1.20–4.44
0.02
1.54
0.57–4.18
0.39
>2.75
6.82
1.55–30.1
0.01
6.34
1.40–28.76
0.02
PTH (pg/mL)
<130
1.00
Reference
≥130–≤585
1.26
0.57–2.79
0.56
2.77
0.61–12.58
0.19
≥585
1.05
0.44–2.49
0.92
2.22
0.42–11.65
0.35
Phosphate > 1.50 mmol/L
1.09
0.61–1.95
0.77
1.43
0.47-4.40
0.53
25 OH vitamin D ≤ 30 ng/mL
2.21
0.66–7.35
0.19
1.07
0.23–4.79
0.92
White race
1.69
0.95–3.04
0.08
6.88
1.82–25.88
0.004
HR = hazard ratio, CI = confidence interval, TAP = total alkaline phosphate, and PTH intact parathyroid hormone. Adjusted for age, phosphate, calcium, PTH, TAP, diabetes, systolic BP, 25-OH vitamin D, alanine transaminase and albumin, and serum calcium categories based on KDOQI reference range.
