International Journal of Nephrology / 2018 / Article / Tab 1

Clinical Study

Prognostic Factors for Survival and Relapse in ANCA-Associated Vasculitis with Renal Involvement: A Clinical Long-Term Follow-Up Study

Table 1

Baseline characteristics of all patients and diagnostic subgroups.

MPAGPAAll
N=47N=38N=85P

Males27 (57.4)26 (68.4)53 (62.4)0.30
Age (years)62 (28-80)52 (22-77)58 (22-80)0.004
Hypertonia14 (29.8)8 (21.1)22 (25.9)0.36
CVD8 (17.0)3 (7.9)11 (12.9)0.21
Creatinine (μmol/l)250 (63-2332)164 (56-1600)208 (56-2332)0.02
GFR (ml/min/1.73 m2)17 (1-91)35 (3-120)24 (1-120)0.01
ANCAPR3-ANCA6 (12.8)34 (89.5)40 (47.1)<0.001
MPO-ANCA41 (87.2)4 (10.5)45 (52.9)
BVAS15 (11-26)19 (5-39)17 (5-39)<0.001
Proteinuria (g/day)<0.57 (14.9)6 (15.8)13 (15.3)0.31
0.5-3.026 (55.3)26 (68.4)52 (61.2)
>3.014 (29.8)6 (15.8)20 (23.5)
Organ involvementRenal47 (100)38 (100)85 (100)
 General symptoms33 (70.2)34 (89.5)67 (78.8)0.03
 Lung13 (27.7)18 (47.4)31 (36.5)0.06
 ENT2 (4.3)23 (60.5)25 (29.4)<0.001
 Skin6 (12.8)9 (23.7)15 (17.6)0.19
 Eyes/mucous membranes3 (6.4)11 (28.9)14 (16.5)0.01
 Nervous system3 (6.4)5 (13.2)8 (9.4)0.49
 Abdominal5 (10.6)1 (2.6)6 (7.1)0.22
 Cardiac2 (4.3)0 (0.0)2 (2.4)0.50

Data are presented as the median (range) for continuous nonnormal variables and as the number (%) for categorical variables.
GPA, granulomatosis with polyangiitis; MPA, microscopic polyangiitis (including two patients with renal limited vasculitis); CVD, cardiovascular disease; GFR, glomerular filtration rate; ANCA, anti-neutrophil cytoplasmic antibody; PR3, proteinase 3; MPO, myeloperoxidase; BVAS, Birmingham vasculitis activity score; ENT, ear, nose, and throat.
P values indicate the comparison between GPA and MPA. Mann-Whitney U test was used for nonnormal continuous variables; Chi-squared test and Fisher’s exact test () were used for categorical variables.
General symptoms: fever, weight loss, arthralgia, myalgia.

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