Prognostic Factors for Survival and Relapse in ANCA-Associated Vasculitis with Renal Involvement: A Clinical Long-Term Follow-Up Study

Table 1

Baseline characteristics of all patients and diagnostic subgroups.

		MPA	GPA	All
		N=47	N=38	N=85	P
Males		27 (57.4)	26 (68.4)	53 (62.4)	0.30
Age (years)		62 (28-80)	52 (22-77)	58 (22-80)	0.004
Hypertonia		14 (29.8)	8 (21.1)	22 (25.9)	0.36
CVD		8 (17.0)	3 (7.9)	11 (12.9)	0.21
Creatinine (μmol/l)		250 (63-2332)	164 (56-1600)	208 (56-2332)	0.02
GFR (ml/min/1.73 m^2)		17 (1-91)	35 (3-120)	24 (1-120)	0.01
ANCA	PR3-ANCA	6 (12.8)	34 (89.5)	40 (47.1)	<0.001
	MPO-ANCA	41 (87.2)	4 (10.5)	45 (52.9)
BVAS		15 (11-26)	19 (5-39)	17 (5-39)	<0.001
Proteinuria (g/day)	<0.5	7 (14.9)	6 (15.8)	13 (15.3)	0.31
	0.5-3.0	26 (55.3)	26 (68.4)	52 (61.2)
	>3.0	14 (29.8)	6 (15.8)	20 (23.5)
Organ involvement	Renal	47 (100)	38 (100)	85 (100)
General symptoms		33 (70.2)	34 (89.5)	67 (78.8)	0.03
Lung		13 (27.7)	18 (47.4)	31 (36.5)	0.06
ENT		2 (4.3)	23 (60.5)	25 (29.4)	<0.001
Skin		6 (12.8)	9 (23.7)	15 (17.6)	0.19
Eyes/mucous membranes		3 (6.4)	11 (28.9)	14 (16.5)	0.01
Nervous system		3 (6.4)	5 (13.2)	8 (9.4)	0.49
Abdominal		5 (10.6)	1 (2.6)	6 (7.1)	0.22
Cardiac		2 (4.3)	0 (0.0)	2 (2.4)	0.50

Data are presented as the median (range) for continuous nonnormal variables and as the number (%) for categorical variables.
GPA, granulomatosis with polyangiitis; MPA, microscopic polyangiitis (including two patients with renal limited vasculitis); CVD, cardiovascular disease; GFR, glomerular filtration rate; ANCA, anti-neutrophil cytoplasmic antibody; PR3, proteinase 3; MPO, myeloperoxidase; BVAS, Birmingham vasculitis activity score; ENT, ear, nose, and throat.
P values indicate the comparison between GPA and MPA. Mann-Whitney U test was used for nonnormal continuous variables; Chi-squared test and Fisher’s exact test () were used for categorical variables.
General symptoms: fever, weight loss, arthralgia, myalgia.