Prognostic Factors for Survival and Relapse in ANCA-Associated Vasculitis with Renal Involvement: A Clinical Long-Term Follow-Up Study

Table 2

(A) Histopathological class of AAV in renal biopsies according to diagnosis and ANCA specificity. (B) Baseline characteristics of patients per histopathological class.

			Histopathological class of AAV in renal biopsies
			Focal	Crescentic	Sclerotic	Mixed	All
			N=29	N=22	N=16	N=17	N=84	P
(A)	Diagnosis	MPA	11 (23.9)	10 (21.7)	14 (30.4)	11 (23.9)	46
		GPA	18 (47.2)	12 (31.6)	2 (5.3)	6 (15.8)	38	0.01
	ANCA	MPO	10 (22.7)	9 (20.5)	14 (31.8)	11 (25.0)	44	0.003
		PR3	19 (47.5)	13 (32.5)	2 (5.0)	6 (15.0)	40
(B)	Males		17 (58.6)	15 (68.2)	11 (68.8)	9 (52.9)	52 (61.9)	0.71
	GFR, ml/min/1.73 m^2		60; (5-120)	14; (2-86)	12; (1-38)	21; (5-88)	24; (1-120)	<0.001
	Age, years		55; (23-78)	50; (23-76)	67; (39-80)	60; (22-80)	58; (22-80)	0.02
	Proteinuria >3 g/day		2 (6.9)	4 (18.2)	8 (50.0)	5(29.4)	19 (22.6)	0.01

Data are presented as the median (range) for continuous nonnormal variables and as the number (%) for categorical variables.
AAV, ANCA-associated vasculitis; ANCA, anti-neutrophil cytoplasmic antibody; MPA, microscopic polyangiitis (including two patients with renal limited vasculitis); GPA, granulomatosis with polyangiitis; MPO, myeloperoxidase; PR3, proteinase 3; GFR, glomerular filtration rate.
Kruskal-Wallis test was used for nonnormal continuous variables and Chi-squared test was used for categorical variables.
The renal biopsy of one MPA patient was not available.