International Journal of Nephrology / 2018 / Article / Tab 2

Clinical Study

Prognostic Factors for Survival and Relapse in ANCA-Associated Vasculitis with Renal Involvement: A Clinical Long-Term Follow-Up Study

Table 2

(A) Histopathological class of AAV in renal biopsies according to diagnosis and ANCA specificity. (B) Baseline characteristics of patients per histopathological class.

Histopathological class of AAV in renal biopsies
FocalCrescenticScleroticMixedAll
N=29N=22N=16N=17N=84P

(A)DiagnosisMPA11 (23.9)10 (21.7)14 (30.4)11 (23.9)46
GPA18 (47.2)12 (31.6)2 (5.3)6 (15.8)380.01
ANCAMPO10 (22.7)9 (20.5)14 (31.8)11 (25.0)440.003
PR319 (47.5)13 (32.5)2 (5.0)6 (15.0)40

(B)Males17 (58.6)15 (68.2)11 (68.8)9 (52.9)52 (61.9)0.71
GFR, ml/min/1.73 m260
(5-120)
14
(2-86)
12
(1-38)
21
(5-88)
24
(1-120)
<0.001
Age, years55
(23-78)
50
(23-76)
67
(39-80)
60
(22-80)
58
(22-80)
0.02
Proteinuria >3 g/day2 (6.9)4 (18.2)8 (50.0)5(29.4)19 (22.6)0.01

Data are presented as the median (range) for continuous nonnormal variables and as the number (%) for categorical variables.
AAV, ANCA-associated vasculitis; ANCA, anti-neutrophil cytoplasmic antibody; MPA, microscopic polyangiitis (including two patients with renal limited vasculitis); GPA, granulomatosis with polyangiitis; MPO, myeloperoxidase; PR3, proteinase 3; GFR, glomerular filtration rate.
Kruskal-Wallis test was used for nonnormal continuous variables and Chi-squared test was used for categorical variables.
The renal biopsy of one MPA patient was not available.

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