Prognostic Factors for Survival and Relapse in ANCA-Associated Vasculitis with Renal Involvement: A Clinical Long-Term Follow-Up Study

Table 3

Diagnostic, histological, and clinical factors to predict patient survival, renal survival, and relapse-free survival (N=82).

			Univariate analysis		Multivariate analysis
Endpoints	Predictors		HR (95% CI)	P	HR (95% CI)	P
Patient survival	Dg MPA		2.71 (1.37-5.35)	0.004
	ANCA MPO		2.67 (1.37-5.19)	0.004	2.12 (1.08-4.17)	0.03
	Histopathological class	Focal	0.29 (0.12-0.69)	0.005
		Crescentic	0.26 (0.10-0.67)	0.006
		Mixed	0.69 (0.30-1.59)	0.38
	Female		0.67 (0.34-1.32)	0.25
	Age ≥58 years		8.50 (3.84-18.79)	<0.001	7.64 (3.44-16.95)	<0.001
	Proteinuria >3g/d		0.94 (0.43-2.04)	0.87
	GFR <30ml/min/1.73m		2.08 (1.07-4.04)	0.03
	Treatment with CYC		0.42 (0.20-0.88)	0.02
Renal survival	Dg MPA		2.71 (1.13-6.52)	0.03
	ANCA MPO		3.17 (1.31-7.64)	0.01	3.10 (1.21-7.95)	0.02
	Histopathological class	Focal	0.11 (0.03-0.41)	0.001
		Crescentic	0.32 (0.11-0.90)	0.03
		Mixed	0.49 (0.18-1.33)	0.16
	Female		0.36 (0.14-0.96)	0.04	0.26 (0.10-0.73)	0.01
	Age ≥58 years		2.50 (1.10-5.71)	0.03
	Proteinuria >3g/day		2.46 (1.08-5.60)	0.03
	GFR <30ml/min/1.73		5.63 (1.92-16.49)	0.002	4.10 (1.35-12.49)	0.01
	Treatment with CYC		0.43 (0.18-1.04)	0.06
Relapse free	Dg MPA		0.48 (0.28-0.82)	0.01	0.48 (0.28-0.82)	0.01
survival	ANCA MPO		0.59 (0.34-1.01)	0.05
	Histopathological class	Focal	1.29 (0.54-3.08)	0.56
		Crescentic	1.82 (0.75-4.41)	0.19
		Mixed	1.07 (0.40-2.82)	0.90
	Female		1.19 (0.70-2.02)	0.53
	Age ≥58 years		0.70 (0.41-1.20)	0.20
	Proteinuria >3g/d		0.75 (0.38-1.49)	0.42
	GFR <30ml/min/1.73m		0.59 (0.35-1.00)	0.05
	Treatment with CYC		2.04 (0.92-4.52)	0.08

Reference groups: ,GPA; , ANCA-PR3; , sclerotic; , male; , age <58 years; , Proteinuria ≤3g/day; , GFR ≥30ml/min; no CYC.