Murine Nephrotoxic Nephritis as a Model of Chronic Kidney Disease

Figure 8

NTS induces chronic renal fibrosis. (a) Representative images of tubulointerstitial fibrotic area visualised by immunohistochemical collagen III staining. (b) Semiquantification of collagen III positive area of the cortex area. (c) Scatter plot showing mRNA expression in whole kidney tissue of Col3a1 as fold change. (d) Fibronectin (Fn1) mRNA expression as fold change. (e) PAI-1 (Serpine-1) mRNA expression as fold change. Data are shown as mean ± SD. NTN groups versus PBS groups; NTN day 7 versus NTN day 21; NTN day 7 versus NTN day 21; and , CD1 NTN versus B6 NTN groups by two-way ANOVA ().

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