Transforming Growth Factor-β Protects against Inflammation-Related Atherosclerosis in South African CKD Patients

Table 2

Correlation between transforming growth factor β isoforms, renal function, lipoprotein particles, inflammation, and markers of atherosclerosis.

Variables	TGF-β1		TGF-β2		TGF-β3
	r value	p value	r value	p value	r value	p value
MABP	− 0.248	0.006	− 0.028	0.763	− 0.136	0.137
Serum creatinine	− 0.348	< 0.001	− 0.237	0.009	− 0.316	< 0.001
Serum albumin	0.247	0.007	0.192	0.036	0.257	0.005
Total cholesterol	0.322	< 0.001	0.226	0.013	0.356	< 0.001
HDL	0.258	0.004	0.262	0.004	0.229	0.012
LDL	0.248	0.006	0.155	0.091	0.263	0.004
TG	0.221	0.016	0.142	0.121	0.269	0.003
Hs-CRP	− 0.183	0.046	− 0.153	0.096	− 0.320	0.001
MCP-1	− 0.212	0.020	− 0.069	0.457	− 0.184	0.045
sCD14	− 0.347	< 0.001	− 0.313	0.001	− 0.318	< 0.001
Endotoxins	− 0.196	0.032	− 0.207	0.023	− 0.139	0.130
LBP	− 0.281	0.002	− 0.402	< 0.001	− 0.403	< 0.001
CIMT	− 0.614	< 0.001	− 0.547	< 0.001	− 0.430	< 0.001

MABP; mean arterial blood pressure; HDL, high density lipoprotein; LDL, low density lipoprotein, TG, triglycerides; Hs-CRP, high sensitivity C-reactive protein; MCP-1, monocyte chemoattractant protein-1; sCD14, serum CD14, LBP, lipopolysaccharide binding protein; CIMT, carotid intima media thickness; TGF, transforming growth factor. Correlation was assessed by Spearman’s correlation coefficient.