Molecular Mechanisms Underlying Accelerated Aging by Defects in the FGF23-Klotho System

Table 1

Interventions that alleviate the aging-like phenotypes in Klotho-deficient mice and/or FGF23-deficient mice and associated changes in serum levels of phosphate and 1,25-dihydroxyvitamin D₃ (Vitamin D).

Interventions	Changes in serum levels
	Phosphate	Vitamin D
Vitamin D-deficient diet	↓	↓
Ablation of vitamin D receptor	↓	↓
Ablation of 1α-hydroxylase	↓	↓
Ablation of Npt2a	↓	↑
Low phosphate diet	↓	↑