Mechanism Underlying Selective Albuminuria in Minimal Change Nephrotic Syndrome

Figure 3

Correlation between the percentage of the area along the capillary wall with foot process effacement and proteinuria in human patients with minimal change nephrotic syndrome with or without acute kidney injury (AKI) (a) and an animal model of minimal change nephrotic syndrome induced by a single or two injections of puromycin aminonucleoside (PAN, n = 5 in each) (b). Patients with MCNS with AKI (n = 13) showed significantly higher levels of serum creatinine and lower levels of serum albumin at biopsy than MCNS patients without AKI (n = 25).

(a)

(b)