Urinary Uromodulin Levels and UMOD Variants in Black South Africans with Hypertension-Attributed Chronic Kidney Disease
Table 1
Characteristics of the study population.
Characteristics
CKD Cases
First-degree relatives
Controls
p-value
p-value#
(N = 71)
(N = 52)
(N = 58)
Male, N (%)
46 (65%)
17 (33%)
26 (45%)
0.023
0.193
Age, years
48 (41-53)
30 (21-50)
41 (34-46)
<0.001
0.046
BMI, kg/m2
28 (24- 30)
27 (25-33)
28 (24-32)
0.634
0.853
Systolic BP, mmHg
141 (132-168)
129 (120-149)
118 (113-130)
<0.001
0.002
Diastolic BP, mmHg
86 (78-97)
76 (72-88)
73 (69-77)
<0.001
0.006
Serum creatinine, μmol/L
769 (482-1116)
76 (64-84)
74 (65-83)
<0.001
0.853
Serum uric acid mmol/L,
0.5 (0.4-0.6)
0.3 (0.3- 0.3)
0.3 (0.3-0.4)
<0.001
0.105
CKD-EPI eGFR, ml/min per 1.73 m2
8 (4-12)
116 (91-139)
121 (99-130)
<0.001
0.409
Urine creatinine, mgdl
83 (58-120)
97 (53-134)
81 (57-140)
0.886
0.791
Uromodulin, μg/ml
0.47 (0.2-3.2)
2.2 (0.9- 8)
2.8 (0.7- 9.5)
<0.001
0.866
Log Uromodulin concentration (μg/ml), mean ± SD
-0.4 ±1.9
0.9 ± 1.2
1.1 ± 1.7
<0.001
0.524
uUMOD/uCr ratio (μg/mg)
0.6 (0.2-3)
3.6 (1.2-8.1)
3 (1.0- 7.0)
<0.001
0.979
Rs13333226 genotype frequencies (AA, AG, GG), %
35, 44, 21
43, 35, 22
40, 41,19
0.868
0.766
Rs13333226 allele frequency (A, G), %
57, 43
60, 40
60, 40
0.592
0.983
Data presented as median (IQR), mean ± SD or n (%), as appropriate -value: CKD cases vs. controls #p-value: first-degree relatives vs. controls P-values from Pearson’s chi square, Kruskal-Wallis, Mann-Whitney and t-test Abbreviations: BMI, body mass index; BP, blood pressure; eGFR, estimated glomerular filtration rate; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration.
