Research Article
Urinary Uromodulin Levels and UMOD Variants in Black South Africans with Hypertension-Attributed Chronic Kidney Disease
Table 3
Relationship between rs13333226 polymorphisms in the UMOD gene and clinical and demographic features in CKD cases.
| | rs13333226 | AA | AG | GG | p-value# |
| | N (%) | 25 | 31 | 15 | | | Gender (M/F) | 15/10 | 19/12 | 12/3 | 0.379 | | Age, years | 44 (40-50) | 49 (44-53) | 47 (42-57) | 0.157 | | Systolic BP, mmHg | 141 (128-166) | 151 (135-170) | 138 (130-141) | 0.327 | | Diastolic BP, mmHg | 87 (78-97) | 90 (79-100) | 82 (76-87) | 0.333 | | Serum creatinine, µmol/L | 823 (505-1141) | 638 (513-1054) | 810 (462-1015) | 0.790 | | CKD-EPI eGFR, ml/min per 1.73 m2 | 6 (4-12) | 9 (4-11) | 7 (5-13) | 0.833 | | Uric acid, mmol/L | 0.4 (0.4-0.6) | 0.5 (0.4-0.6) | 0.5 (0.4-0.5) | 0.666 | | Urine PCR g/mmol | 0.1 (0.1-0.2) | 0.1 (0.1-0.2) | 0.1 (0.0-0.2) | 0.315 | | Log Uromodulin concentration (µg/ml), mean (SD) | 0.3 ± 1.9 | -0.5 ± 1.76 | -1.4 ± 1.7 | |
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Data given as median (interquartile range) unless specified. P values: #Kruskal-Wallis unless specified; earson’s chi square; tests. BP, blood pressure; eGFR, estimated glomerular filtration rate; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; PCR, protein: creatinine ratio. |
