ACTH Treatment for Management of Nephrotic Syndrome: A Systematic Review and Reappraisal

Table 8

Summary of studies on ACTH in lupus nephritis.

Study	N	Study protocol	Mean initial lab values	Study outcome	Complications
Lupus nephritis (LN)
Khastgir et al. [6]	2	Acthar gel: 80 units twice weekly for 6 months	N/A	2 partial; remissions	None
Madan et al. [2]	2	Acthar gel: 80 units twice weekly for 6 months	SCr: 1.0 mg/dl; SrA: 1.7–1.8 g/dl; Proteinuria: 8000–19890 mg/d	SCr: 0.8–1/1 mg/dl; SrA: 2.4–3.3 g/dl; Proteinuria: 1089–2454 mg/d; 87.3% reduction in proteinuria; 2 partial remissions	None
Fiechtner and Montroy [26]	10	Acthar gel: 80 units per day for 7–15 days	N/A	Improvement in joint and active skin problems	Edema (n = 1)
Bomback et al. [5]	1	Acthar gel: 40 units thrice weekly for 5 months	Proteinuria: 1340 mg/day	Proteinuria: 2290 mg/day; No response	Weight gain (n = 1)

SCr, serum creatinine; SrA, serum albumin.