Bidirectional Interaction of Thyroid-Kidney Organs in Disease States

Table 3

Distribution and mean values of thyroid autoantibodies in thyroid-kidney dysfunction.

eGFR	AutoAbs
	TG	Anti-TG Ab	AMA (anti-TPO Ab)	Anti-TSH R blocking Ab (TBA)	Thyrotropin-binding inhibitory IG (TBII)	Thyroid-stimulating Abs (TSI)	Na^+/I^-symporter Ab (NIS)	HLA-DR3 gene	CTLA4 gene
—	M/F:1/3 mean ± SD 304.76 ± 206.40	M/F:4/6 mean ± SD 154.91 ± 187.69	M/F:5/7 mean ± SD 958.12 ± 1215.34	M/F:0/4 mean ± SD 26.99 ± 31.79	1/45(2.2%)	1/45(2.2%)	—	—	—
eGFR ≥ 90	1/45(2.2%)	1/45	—	2/45 (4.4%)	—	1/45(2.2%)	—	—	—
eGFR 60–89	—	1/45	1/45 (2.2%)	1/45 (2.2%)	—	—	—	—	—
eGFR 30–44	—	1/45	3/45 (6.6%)	—	—	—	—	—	—
eGFR 45–59	—	2/45	—	—	—	—	—	—	—
eGFR 15–29	—	—	1/45 (2.2%)	—	—	—	—	—	—
eGFR < 15	—	—	—	—	—	—	—	—	—

AMA, antimicrosomal antibody (former antithyroid peroxidase antibody); anti-TSH R Abs, antithyrotropin receptor antibodies; CTLA 4 gene, T cell regulatory gene; eGFR, estimated glomerular filtration rate; HLA-DR3, human leukocyte antibody-DR3; IU/ml, international unit per milliliter; NIS, sodium/iodide symporter antibodies; SCH, subclinical hyperthyroidism; SD, standard deviation; TG, thyroglobulin; TSI, thyroid-stimulating immunoglobulin ≤16% inhibition in adults and children, 16–100% inhibition in grave's disease. TBII ≤1.75 IU/l is considered normal.