Bidirectional Interaction of Thyroid-Kidney Organs in Disease States

Table 6

Mean and standard deviation values of biochemical tests before and after treatment with thyroid hormone replacement therapy in thyroid and kidney dysfunction.

Biochemical test

Disease

Primary hypothyroidism (mean ± SD, median)

Subclinical hypothyroidism (mean ± SD)

Primary hyperthyroidism (mean ± SD)

Subclinical hyperthyroidism (mean ± SD)

Euthyroidism (mean ± SD)

Before Tx

After Tx

value

Before Tx

After Tx

Before Tx

After Tx

value

Before Tx

After Tx

Before Tx

After Tx

TSH (NND)

N = 11 244.88 ± 392.62 median: 100; Q1: 40.5; Q3: 211.2; IQR: 170.7

N = 11 24.28 ± 29.55 median: 10.8; Q1: 2.44; Q3:33.6; IQR: 31.16

Result 1⟶ value: 0.003 (SS), z value: −2.93, value: 0; result 2: SS

—

—

—

—

—

—

—

1.44 ± 0.64

—

fT4 (ND)

N = 10 0.44 ± 0.31

N = 10 1.14 ± 0.41

value: 0.985 (NS); value: 0.99 (NS)

—

—

N = 2 37.29 ± 24.57

N = 2 2.54 ± 1.36

—

—

—

1.16 ± 0.16

—

fT3 (ND)

N = 3 1.29 ± 0.68

N = 3 2.43 ± 0.82

ID

—

—

N = 2 12.1 ± 4.3

N = 2 1. 60 ± 0.99

ID

—

—

2.12 ± 0.22

—

Total CPK (ND)

N = 5 18504.2 ± 31659.8

N = 5 624.4 ± 653.44

value: 1 (NS)

—

—

—

—

—

—

—

—

—

Total cholesterol (ND)

N = 3 352.6 ± 20.19

N = 3 19 ± 18.47

ID

—

—

—

—

—

—

—

—

—

Serum creatinine (ND)

N = 11 1.67 ± 0.27

N = 11 1.45 ± 0.49

value: 0.957 (NS); value: 0.981(NS)

—

—

N = 2 3.39 ± 1.79

—

—

—

—

1.14 ± 0.24

—

CPK, creatine phosphokinase; fT3, free triiodothyronine; fT4, free thyroxin; ID, insufficient data;IQR, interquartile range; N, number; ND, normally distributed; NDD, nonnormally distributed; NS, not significant; Q1, first quartile ; Q3, third quartile; SD, standard deviation; SS, statistical significant; TSH, thyroid stimulating hormone; Tx, treatment.