Biomarkers for Diagnosis and Prediction of Outcomes in Contrast-Induced Nephropathy

Table 3

Optimal cutoff values for biomarkers in predicting CIN.

	Cutoff point	Sensitivity	Specificity	PPV	NPV
sNGAL_p (ng/ml)	63.15	0.84	0.45	0.50	0.81
sNGAL_24 (ng/ml)	80.81	0.74	0.52	0.47	0.78
sNGAL_48 (ng/ml)	72.95	0.70	0.62	0.50	0.79
sCystatin C_p (ng/ml)	893.43	0.37	0.96	0.88	0.70
sCystatin C_24 (ng/ml)	856.59	0.52	0.90	0.75	0.77
sCystatin C_48 (ng/ml)	764.32	0.52	0.86	0.67	0.78
Sβ2M_p (μg/ml)	3.6	0.88	0.45	0.48	0.87
Sβ2M_24 (μg/ml)	4.3	0.71	0.61	0.51	0.78
Sβ2M_48 (μg/ml)	5.1	0.57	0.88	0.72	0.80
IL18_p (pg/ml)	182.0	0.48	0.80	0.60	0.71
IL18_24 (pg/ml)	161.2	0.50	0.67	0.48	0.68
IL18_48 (pg/ml)	116.6	0.75	0.60	0.50	0.81

sNGAL and uNGAL, serum and urine neutrophil gelatinase-associated lipocalin; sIL18 and uIL18, serum and urine interleukin 18; sβ2M, serum beta 2 microglobulin.