Development and Validation of Creatinine-Based Estimates of the Glomerular Filtration Rate Equation from 99mTc-DTPA Imaging in the Malaysian Setting
Table 1
Demographic and clinical characteristics.
Variables
All patients (n = 187)
Development cohort (n = 94)
Validation cohort (n = 93)
value
Age (years)
55.3 ± 14.2
55.9 ± 14.1
54.7 ± 14.3
0.56
Gender (male)
97 (51.9)
46 (48.9)
51 (54.8)
0.41
Weight (kg)
65 ± 14
65 ± 15
65 ± 13
0.52
Height (cm)
158 ± 10
159 ± 10
158 ± 10
0.76
Body mass index (kg/m2)
26.0 ± 5.4
25.9 ± 5.4
26.1 ± 5.4
0.54
Ethnicity
0.36
(i) Malay
1165 (88.2)
84 (89.4)
81 (87.1)
(ii) Chinese
16 (8.6)
9 (9.6)
7 (7.5)
(iii) Indian
2 (1.1)
0 (0)
2 (2.2)
(iv) Orang Asli
2 (1.1)
1 (1.1)
1 (1.1)
(v) Others
2 (1.1)
0 (0)
2 (2.2)
99mTc-DTPA measured GFR (ml/min)
40.6 ± 19.9
40.7 ± 20.1
40.4 ± 19.8
0.58
Plasma creatinine (μmol/l)
124 (86–209)
132 (86–214)
117 (87–208)
0.33
Estimated GFR by Cockcroft–Gault (eGFRCG) (ml/min)
46.2 (28.5–72.6)
45.2 (26.8–71.1)
49.2 (31.1–72.8)
0.34
Estimated GFR by MDRD (eGFRMDRD) (ml/min)
49.4 (27.1–73.0)
46.4 (24.9–66.7)
50.8 (28.7–82.1)
0.25
Estimated GFR by CKD-EPI (eGFRCKD-EPI) (ml/min)
47.8 (26.0–74.7)
46.8 (23.7–69.0)
49.7 (28.2–85.8)
0.24
Estimated GFR by the new equation (eGFRNE) (ml/min)
43.0 ± 13.2
42.0 ± 13.2
43.9 ± 13.1
0.91
Data are expressed as mean ± SD, n (%), or median (lower quartile–upper quartile). BMI, body mass index; 99mTc-DTPA, Technetium-99m-diethylenetriaminepentaacetic acid, eGFR, estimated glomerular filtration; MDRD, Modification of Diet in Renal Disease; CKD-EPI, Chronic Kidney Disease-Epidemiology Collaboration; NE, new equation.
