Research Article
Anti-Factor H Antibodies in Egyptian Children with Hemolytic Uremic Syndrome
Table 4
Treatment regimens and different outcomes among HUS patients.
| | Parameter | Typical HUS (n = 22) | Anti-FH-positive aHUS (n = 12) | Anti-FH-negative aHUS (n = 16) |
| | A: treatment regimens | | Renal dialysis | 15 (68.2%) | 10 (83.4%) | 12 (75.1%) | | PEX ± FFP | 0 | 3 (25%) | 6 (37.5%) | | FFP transfusion only | 1 (4.5%) | 4 (33.3%) | 10 (62.5%) | | Combined PEX + IS other drugs | 0 | 5 (41.7%) | 0 | | Diuretics | 21 (95.5%) | 11 (91.7%) | 15 (93.8%) | | Anticonvulsants | 1 (4.5%) | 0 | 1 (6.3%) |
| | B: different outcomes | | CR with full renal recovery | 21 (95.5%) | 6 (50%) | 7 (43.8%) | | Adverse outcome | | | | | CRF | 0 | 4 (33.3%) | 5 (31.3%) | | Other organ complications | 0 | 1 (8.3%) | 2 (12.5%) | | Death | 1 (4.5%) | 1 (8.3%) | 2 (12.5%) |
| | C: anti-FH titer in relation to disease outcome in the anti-FH-positive aHUS | | Disease outcome | Complete remission (n = 6) | Adverse sequela/deaths (n = 6) | p value | | Anti-FH titer (mean ± SD) in AU/ml | 3399.2 ± 3487.9 | 3481.7 ± 2365.1 | 0.9 |
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PEX: plasma exchange, FFP: fresh frozen plasma, IS: immunsupressants, CR: complete remission, and CRF: chronic renal failure. Analysis was done using chi-square test.
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