International Journal of Nephrology / 2021 / Article / Tab 6 / Research Article
Medicine Dose Adjustment Practice and Associated Factors among Renally Impaired Patients in Amhara Regional State, Ethiopia Table 6 Factors associated with dose adjustment practice in patients with renal impairment admitted to medical wards at Amhara region referral hospitals, Amhara, Ethiopia, in 2020 (n = 424).
Variable Inappropriate dose adjustment Univariable analysis Multivariable analysis Yes No COR 95% CI AOR 95% CI Age <20 5 (38.5) 8 (61.5) 1 1 20–40 60 (42.3) 82 (57.7) 0.79 1.17 (0.36–3.75) 0.17 5.0 (0.49–52.1) 41–60 88 (50.3) 87 (49.7) 0.41 1.61 (0.50–5.14) 0.41 2.6 (0.25–27.4) >60 57(60.6) 37 (39.4) 0.13 2.46 (0.74–8.11) 0.88 0.8 (0.76–9.2) Sex Male 103 (45.4) 124 (54.6) 1 1 Female 107 (54.3) 90 (45.7) 0.06 1.43 (0.97–2.1) 0.88 0.95 (0.47–1.90) Residence Rural 117 (58.2) 84 (41.8) 0.01 1.94 (1.32–2.86) 0.81 0.91 (0.41–2.01) Urban 93 (41.7) 130 (58.3) 1 1 Occupation Employed 109 (41.2) 155 (58.8) 1 1 Unemployed 101 (63.1) 59 (36.9) <0.001 2.43 (1.62–3.64) 0.04 3.18 (1.45–7.01) Education No formal education 119 (62.9) 70 (37.1) <0.001 3.68 (2.25–6.03) 0.91 2.39 (0.86–6.61) Primary 39 (54.1) 33 (45.9) 0.02 2.56 (1.39–4.70) 0.61 1.30 (0.46–3.61) Secondary 16 (32.6) 33 (67.4) 0.89 1.05 (0.51–2.14) 0.62 1.33 (0.41–4.31) Higher education 36 (31.5) 78 (68.5) 1 1 Presence of comorbidity Yes 189 (50.5) 185 (49.5) 0.25 0.70 (0.39–1.28) 0.18 14.1 (0.28–696.18) No 21 (42.0) 29 (58.0) 1 1 Stage in CKD Stage 3 21 (39.6) 32 (60.4) 1 Stage 4 15 (40.5) 22 (59.5) 0.93 1.03 (0.44–2.44) Stage 5 26 (50) 26 (50) 0.28 1.52 (0.70–3.301) Length of service ≤1 year 35 (68.6) 16 (31.4) 0.001 2.87 (1.52–5.42) 0.21 1.82 (0.70–4.67) 2 years 45 (62.5) 27 (37.5) 0.01 2.19 (1.29–3.7) 0.73 1.14 (0.52–2.50) ≥3 years 130 (43.1) 171 (56.9) 1 1 Specialty GP 20 (29.4) 48 (70.6) <0.001 3.08 (1.72–5.51) 0.21 1.75 (0.72–4.26) Internist 190 (53.3) 166 (46.7) 1 1 Weight 61.4 (±9.2) 59.3 (±9.24) 0.02 1.02 (1.00–1.04) 0.22 0.97 (0.94–1.01) Number of comorbidities 1.58 (±0.85) 2.84 (±1.0) <0.001 3.99 (2.99–5.31) 0.01 1.65 (1.09–2.48) SrCr 3.02 (±2.30) 3.03 (±2.42) 0.96 0.99 (0.92–1.08) GFR 31.67 (±14.30) 33.74 (±15.02) 0.14 0.99 (0.97–1.00) 0.58 0.9 (0.97–1.01) Number of medications 5.04 (±1.36) 3.02 (±1.18) <0.001 3.29 (2.63–4.10) <0.001 3.20 (2.28–4.49)
