PAC-Mediated AKI Protection Is Critically Mediated but Does Not Exclusively Depend on Cell-Derived Microvesicles

Figure 3

Interstitial fibrosis, evaluated after Masson trichrome staining. (a–d) The results of the respective preconditioning groups, always compared with “Control,” “IRI” (ischemia reperfusion injury), “IRI + SECR” (secretome), “IRI + MV” (microvesicles), and “IRI + SECR + MV,” respectively. Interstitial matrix accumulation did not significantly differ at all between any of the groups. (e–h) (Magnification ×40) representative images of four group (labelled). The rectangles in (f, g) surround areas of matrix deposition.

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