Effects of Standardized Brazilian Green Propolis Extract (EPP-AF®) on Inflammation in Haemodialysis Patients: A Clinical Trial
Table 2
Inflammatory and immunological parameters.
Parameters
Time
values
Baseline (t1)
Treatment (t2)
Posttreatment (t3)
t1 vs. t2
t1 vs. t3
IFN-y (pg/ml)
12 (11–22)
11 (10–16)
10 (8–46)
0.005
0.003
IL-10 (pg/ml)
27 (22–32)
27 (21–32)
25 (17–36)
0.20
0.03
IL-12p70 (pg/ml)
11 (10–15)
10 (8–14)
10 (8–21)
0.11
<0.001
IL-13 (pg/ml)
14 (8–52)
10 (6–26)
12 (5–40)
0.042
0.012
IL-17 (pg/ml)
15 (12–20)
12 (10–16)
13 (9–28)
0.039
0.003
IL-1Ra (pg/ml)
28 (18–47)
25 (15–38)
19 (14–55)
0.008
0.016
IL-1α (pg/ml)
19 (12–51)
19 (11–48)
20 (9–71)
0.060
0.033
IL-1β (pg/ml)
15 (10–44)
12 (9–30)
11 (8–30)
0.13
0.002
IL-4 (pg/ml)
18 (13–37)
14 (10–29)
17 (12–36)
0.12
0.40
IL-6 (pg/ml)
93 (52–164)
76 (42–170)
68 (33–137)
0.051
0.003
IL-8 (pg/ml)
556 (282–880)
323 (215–566)
358 (222–643)
0.009
<0.001
TNF-α (pg/ml)
155 (112–215)
120 (89–152)
109 (76–146)
<0.001
<0.001
IL: interleukin; IFN: interferon; TNF: tumour necrosis factor. t1 vs. t2: baseline vs. treatment; t1 vs. t3: baseline vs. posttreatment. Data are expressed as the median (IQR). values were measured by the Wilcoxon signed-rank exact test and Wilcoxon signed-rank test with continuity correction.
